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GLP-1 receptor agonists are now used for the treatment of type 2 diabetes and obesity. Looking back, GLP-1 was found to be a cleavage product of proglucagon processing.A key breakthrough came from the discovery of exendin-4.Exendin-4 is a peptide with agonistic properties at the GLP-1 receptor but resistance to degradation by DPP-4.Semaglutide, the first oral GLP-1 receptor agonist, marked the next milestone.
Medicilon provides GLP-1 drug discovery, CMC research (API + formulation), pharmacodynamics research, PK study, GLP-1 safety evaluation and other services.
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