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Analysis and testing platform/chemical process testing platform of Medicilon

2020-06-22
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Platform Introduction

Shanghai Medicilon chemical analysis and testing platform is a shared platform that provides analysis and testing services.

The platform has a professional and refined scientific research service team. There are more than 80 devices including NMR, SFC, UPCC, ICP-MS, IC, LC-MS/MS, Prep-HPLC, DSC, TGA, etc. The classification registration sample management system is implemented, which implements automatic management and clear charging, and mainly serves the fields of chemistry, medicine, and chemical industry. At present, the platform has established long-term cooperative relations with many companies, providing strong support for the scientific research work of each company.

Cooperation model

(1) Test class
Sign an annual agreement, monthly payment or quarterly payment;

(2) Project category
Sign a single project, you can sign an annual framework agreement.

Undertake business:

(1) Can undertake business-test category:

Serial number
Instrument/Type
Instrument model
1
Nuclear magnetic resonance NMR
Bruker 400 MHz
2
LC-MS
Shimadzu LC-MS 2020
Waters UPLC-Qda
Agilent 6120
3
GC-MS
Agilent 7890B;
Shimadzu GC-MS 2020
4
High performance liquid chromatography HPLC
Agilent 1200;
Shimadzu 20AD
5
Chiral sample analysis UPCC/HPLC
Waters UPCC
Shimadzu 20AD
6
Residual solvent analysis GC-HS
Agilent GC-HS 7890B
Shimadzu GC-2010 plus
7
Ion content analysis IC
Thermo IC 5500
8
Metal element analysis ICP-MS
PE NexION 1000
9
UV spectrum UV
PE LAMBDA 365
10
Infrared spectrum IR
PE Spectrum Two
11
Optical rotation test OR
Anto Paar MCP5300
12
Differential Thermal Analysis DSC
METTLER DSC 3
13
Thermogravimetric analysis TGA
METTLER TGA 2
14
Moisture test KF
METTLER V30S
METTLER C30SX
15
Ignition residue test ROI
Muffle
16
Loss on drying test LOD
Oven
METTLER HX 204
17
Melting point test MP
METTLER MP 70
18
Solution Clarity Analysis
Clarifier
19
Solubility test
Visual method
20
Microbial limit test
Pharmacopoeia Standard Test

(2) Can undertake business-analysis projects:

Serial number
project
Use the instrument
1
diQ-NMR
NMR
2
Structural confirmation
NMR
3
Impurity standardization (declaration)
HPLC, GC-HS, moisture meter, ROI
4
API standardization (declaration)
HPLC, GC-HS, moisture analyzer, ROI, titrator
5
Compound main peak preparation
Pre-HPLC
6
Impurity preparation
Pre-HPLC
7
Chiral method screening and splitting
SFC
8
Stability test
Stability box, HPLC, GC-HS and physical and chemical instruments
9
GC-HS methodology development and validation
GC-HS
10
GC-MS methodology development and validation
GC-MS
11
HPLC methodology development and validation
HPLC
12
ICP-MS method development and verification
ICP-MS
13
IC method development and verification
IC
14
LC-MS-MS method development and verification
LC-MS-MS
15
Microbial limit method development and verification
Microbiology laboratory


Main large instruments:

(1)

Nuclear Magnetic Resonance Spectrometer NMR            

Nuclear Magnetic Resonance Spectrometer NMR

model:
Bruker Avance Ⅲ HD 400 MHz

 Main functions: suitable for molecular structure analysis, content determination, known structure confirmation and unknown structure speculation and reaction mechanism research in chemistry, medicine, chemical industry, etc. It can test the NMR spectrum of various cores such as H, C, F, P, B and so on; equipped with PABBO SP probe, it can be used for 1H, 13C, DEPT, NOESY, COSY, HMBC, HSQC and other 1D and 2D homonuclear and heteronuclear Related experiments and variable temperature experiments.


(2)

Inductively coupled plasma mass spectrometer ICP-MS            

Inductively coupled plasma mass spectrometer ICP-MS

model:

PE NexION 1000



 Main function : suitable for the research of metal elements in chemistry, biology, medicine, clinical and so on. It can measure more than 80 elements at the same time, with high sensitivity, simultaneous multi-element rapid analysis, suitable for trace or ultra-trace element analysis of complex systems (10-9~10-12g/L). Such as research techniques for the control and analysis methodology of elemental impurities.


(3)

Ion Chromatography IC            



Ion Chromatography IC

model:

Thermofish ICS5000+ (conductivity and amperometric detector)





  Main functions: Widely used in the analysis and methodological studies of anions, cations, organic acids, organic amines, cyanide, sulfur ions, iodide ions, sugars and amino acids in samples from industries such as environment, materials, chemicals, food, biology, and medicine .



(4)

Triple quadrupole mass spectrometer LC-MS-MS            



Triple quadrupole mass spectrometer LC-MS-MS

model:

Agilent 6410





  Main functions: suitable for molecular weight determination in chemical, pharmaceutical, chemical and other aspects, detection and methodological study of trace PGI impurities from ppm to ppb levels.



(5)

Chiral sample analysis            



Chiral sample analysis

model:

Waters UPC2/8 column screening




Chiral sample analysis            





model:

Shimadzu 20AD/12 column screening






  Main functions:suitable for screening and development of chiral compounds in chemistry, medicine, chemical industry, etc., ee value, chiral purity determination, etc. Provide a powerful method for the resolution of chiral compounds.


(6)

Chiral split SFC            


Chiral split SFC

model:

SFC80/SFC150



Main function: suitable for the resolution of chiral compounds from mg to 100g in chemistry, medicine, chemical industry, etc.


(7)

Gas chromatography-mass spectrometer GCMS            




Gas chromatography-mass spectrometer GCMS

model:

Agilent 5977A




Gas chromatography-mass spectrometry GCMS            


Model: Shimadzu GC-MS 2020






 
Main function: Suitable for environment, food, petrochemical industry, biomedicine, flavor and fragrance, forensic poison, tobacco and other industries. It can qualitatively and quantitatively detect and analyze small molecular organic compounds with low boiling point and good thermal stability, especially suitable for low boiling point Methodological studies on trace impurities such as potentially genotoxic impurities.



(8)

Pre-LC            




Pre-LC

model:

Waters 2545-QDa150ml/min



Preparative chromatography           


Preparative chromatography

model:

Gilson 306 50ml/min



Main functions: suitable for separation and purification of organic synthesis products of compounds in chemistry, medicine, chemical industry, etc., preparation and separation of trace impurities in raw materials and preparations.


Other instruments

infrared spectrometer               




infrared spectrometer

model:

PE  Spectrum TWO




UV spectrometer          


UV spectrometer

model:

PE  Lambda 365




Polarimeter           



Polarimeter

model:

Anton Paar MCP5300




Moisture Analyzer            

Moisture Analyzer:

model:

METTLER TOLEDO V30S




Moisture Analyzer src=            


Moisture Analyzer:

model:

METTLER TOLEDO V30S




Potentiometric titrator            




Potentiometric titrator:

model:

METTLER TOLEDO T50





contact us:
Contact: 021-58591500 or marketing@medicilon.com

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