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Address: 470 Wildwood Ave, Woburn, MA 01801 (America)
Tel: +1(626)986-9880
Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK
Tel: 0044 7790 816 954
Email: marketing@medicilon.com
Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)
Postcode: 201299
Tel: +86 (21) 5859-1500 (main line)
Fax: +86 (21) 5859-6369
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Business Inquiry
Global:
Email:marketing@medicilon.com
+1(626)986-9880(U.S.)
0044 7790 816 954 (Europe)
China:
Email: marketing@medicilon.com.cn
Tel: +86 (21) 5859-1500
Shanghai Medicilon has extensive experience in pharmacokinetics. Our pharmacy section provides customers with high-quality pharmacokinetic services from all small molecules to large molecules (proteins and antibodies), including in vitro ADME and in vivo pharmacokinetics and biological analysis. The animal species involved are non-human primates, dogs, mice, rats, rabbits, guinea pigs, etc. Among them, non-primate platforms and experimental platforms using isotope proteins/antibodies were recognized as important laboratory platforms by the Shanghai Municipal Government. The company relies on advanced analytical testing equipment and analytical laboratories that meet GLP requirements, and cooperates with GLP laboratory animal centers and Phase I clinical centers that meet AAALAC certification to provide pharmacokinetic technical services for domestic and foreign biomedical companies. .
Medicilon’s pharmacokinetics mainly studies changes in drug metabolism in the body, including the process of drug absorption, distribution, metabolism and elimination (ADME) in the body. The purpose of Medicilon is to provide high-quality data and a fast turnaround period to support various drug development, preclinical research and clinical research. The ultimate goal is to provide customers with not only a strong effect, small toxic and side effects; but also to have a good The pharmacokinetic properties of the drug. Pharmacokinetic services include: pre-clinical pharmacokinetics, pharmacokinetic studies using isotope labels, and pre-clinical pharmacokinetic application materials for new drugs.
Mainly include drug metabolic stability in the body, P450 induction and inhibition, metabolic pathway research, metabolic product identification and other research projects, involving animals include rats, mice, rabbits, dogs, monkeys and so on.
in the body, P450 induction and inhibition, metabolic pathway research, metabolic product identification and other research projects, involving animals include rats, mice, rabbits, dogs, monkeys and so on.
Evaluation capacity: Medicilon completes an average of 8 overall outsourcing studies for new drug applications and more than 1,000 individual studies for new drug applications each year. The tested varieties include small molecule drugs, biotechnology drugs and natural product drugs
Software application: WinNolin and WastonLim software are used for data processing and analysis of pharmacokinetic research and laboratory management
Determination of plasma protein binding rate
Plasma stability test
Microsomal metabolism test
CYP450 inhibition test
CYP450 induction experiment
Metabolism speculation
Confirmation of metabolites
Metabolic pathway speculation
Confirmation of metabolic pathways
Transmembrane Transport Experiment
Drug-drug interaction
Evaluation ability: Medicilon puya completes an average of 8 Package studies for new drug declaration and more than 1,000 individual studies for new drug declaration each year. The tested varieties include small molecule drugs, biotechnology drugs and natural product drugs
Software application: WinNolin and WastonLim software are used for calculation processing and analysis laboratory management of pharmacokinetic data
Plasma Kinetics Study
Organizational distribution research
Excretion study
Pharmacokinetic
• Method development and validation (GLP, Non-GLP)
• Analysis of biological samples
• Various pharmacokinetic animal experiments
(Tumor model animals, gender differences, bioavailability, multi-cycle crossover experiments, cassette drug delivery, blood-brain barrier penetration studies)
• Drug stability study in plasma and vehicle
• Drug interaction studies
• In vitro metabolic stability studies
• CYP450 enzyme inhibition study
• Plasma protein binding rate
• Organizational distribution research
• Excretion studies
• Metabolism speculation and identification
• Pharmacokinetic studies of iodine-labeled protein/antibody drugs
• Organizational distribution
• Mass balance analysis
• Declaration materials that meet FDA and SFDA new drug registration requirements
-Small molecule chemicals
-Chinese medicine
-Macromolecular protein drugs
– Monoclonal antibodies
1. Design and implement DMPK research plan;
2. Analyze and sort out the preclinical pharmacokinetics (DMPK) and toxicokinetic experimental data;
3. Provide pharmacokinetic reports for customers and provide pharmacokinetic experiment programs;
4. Design DMPK experiment plan;
5. Has rich experience in the design and implementation of preclinical pharmacokinetic and toxicokinetic research programs;
contact us
Email: marketing@medicilon.com
Phone: 021-58591500
Medicilon Drug Metabolite Analysis Service
Medicilon Metabolomics Technical Services