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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Sep 21,2015
Noise of Channel Molecular Helps to Keep Healthy Cells
    Complex networks are noisy, whether they constitute food webs, power grids, or cells. And when networks buzz and crackle beyond normal bounds, bad things can happen: ecosystems can collapse, power grids can leave us in the dark, and cells can tumble into cancerous states.     All these networks are amenable to similar mathematical treatments, says aRead more
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Sep 21,2015
Gene Therapy Business Could Be Raised Multimillion Dollars
    Research and Markets recently released its "Global Gene Therapy Market Outlook 2018,” which predicts that the gene therapy business could be a multimillion dollar industry by the end of 2018, potentially reaching $500 million by 2020.     REGENXBIO, the gene therapy company formed by the collaboration between FoxKiser and James M. Wilson, M.D., Ph.D., professorRead more
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Sep 21,2015
Excipient manufacturers pay attention to stability test
A few days ago, the International Pharmaceutical Excipients Association (IPEC) claimed that excipient manufacturers have successively received inappropriate requests for stability data from some regulatory authorities and pharmaceutical companies. For this reason, these excipient manufacturers have threatened to interrupt the supply chain. These requirements began last year. However, the number of requests made by regulatoryRead more
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Excipient manufacturers pay attention to stability test
Sep 18,2015
Findings Say That Apoptosis May Be Controlled by Mitochondrial Protein
    A protein embedded in the surface of mitochondria opens the door to apoptosis, causing cells to experience severe power failures, according to new work by researchers at Temple University School of Medicine. The study, appearing in Molecular Cell, suggests that blocking the door with a small-molecule inhibitor could be key to the treatment of cardiovascular
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Sep 18,2015
CRISPR Exploits Vulnerability of Sickle Cell Disease
    Sickle Cell Disease (SCD), also known as sickle cell anaemia (SCA) and drepanocytosis, is a hereditary blood disorder, characterized by an abnormality in the oxygen-carrying haemoglobin molecule in red blood cells.  This leads to a propensity for the cells to assume an abnormal, rigid, sickle-like shape under certain circumstances.       A direct consequence of naturalRead more
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Sep 17,2015
Hearts Build New Muscle with Simple Protein Patch
    Most people survive heart attacks immediately, but the damage to the muscle and scarring which results takes a toll that eventually leads to heart failure — of which many patients die within five to six years of developing.     An international team of researchers has identified a protein that helps heart muscle cells regenerate after aRead more
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Sep 17,2015
Some Obesity May Be Caused By an Off Balance Immune System
    Immune cells are usually described as soldiers fighting invading viruses and bacteria. But they may also be waging another battle: the war against fat.   Obesity is not just a matter of "bad genes” or unhealthy lifestyles. It also involves immunological mechanisms. In fact, certain immune cells appear to influence fat tissue, controlling the storage andRead more
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Some Obesity May Be Caused By an Off Balance Immune System
Sep 17,2015
China R&D innovation, investment catching up to the global markets
HONG KONG – Chinese pharmaceutical firms have come a long way, transforming themselves from makers of active pharmaceutical ingredients (APIs) to innovative drug developers in a couple of decades. The secret sauce in that transformation has been investment in R&D. Now, more companies are looking toward international markets, growing more comfortable with international compliance rulesRead more
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China R&D innovation, investment catching up to the global markets
Sep 16,2015
Two Key Genes Play A Critical Role in Skin and Organ Development
Knocking out one or both crucial regulatory genes caused cleft lip, skin barrier defects, and a host of other developmental problems in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania.       The study ("The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalianRead more
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Two Key Genes Play A Critical Role in Skin and Organ Development
Sep 15,2015
Impaired Mitochondrial Homeostasis and Neurodegeneration
Mitochondria lie at the heart of energy provision for most cells and tissues, providing energy for the balance against negative entropy, for maintenance of cell structure and for active signaling.  Scientists at the Gladstone Institutes report that they have shown for the first time that impairments in mitochondria can deplete cellular energy levels and cause.
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Impaired Mitochondrial Homeostasis and Neurodegeneration