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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Aug 13,2015
Zombie Cells Survive and Divide Amidst Heavy Mutations
    Scientists at the University of Southern California say they have developed a yeast model to study a gene mutation that disrupts the duplication of DNA, causing massive damage to a cell's chromosomes, while somehow allowing the cell to continue dividing.       The result is a group of cells that by all rights shouldn't be ableRead more
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Zombie Cells Survive and Divide Amidst Heavy Mutations
Aug 12,2015
Gene Discovered as Cause of Mitral Valve Prolapse
    Although heart disease still represents the leading cause of death worldwide, genomic studies have increasingly helped scientists zero in on a number of likely causes. For example, mitral valve prolapse (MVP), which affects 2-3% of the population, has not been previously associated with a specific genetic mutation even though it was seen to occur frequentlyRead more
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Aug 12,2015
Researchers Learn How Bacteria Use Toxins to Disable Immune Response
    Scientists at Ohio State University say they have discovered how bacteria use toxins to interrupt the immune response. The researchers say it’s important to understand how the toxins work because they are key to enabling bacteria to cause disease.     Toxins typically go after molecules that are either scarce or whose role is to send importantRead more
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Aug 11,2015
3D Scaffold System May Lead to Novel Anticancer Therapies
    Scientists at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones. By placing cancer cells in a three-dimensional scaffold and subjecting them to the forces that push, pull, and continually flow through the body, the researchers are better ableRead more
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3D Scaffold System May Lead to Novel Anticancer Therapies
Aug 11,2015
Scientists Image Peptide-Binding GPCR Activity for First Time
    Researchers at the National Institutes of Health say they used atomic level images to show how the neuropeptide hormone neurotensin might activate its receptors. Their description reportedly is the first of its kind for a neuropeptide-binding G protein-coupled receptor (GPCR), a class of molecules involved in a wide range of disorders and the target ofRead more
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Scientists Image Peptide-Binding GPCR Activity for First Time
Aug 10,2015
Researchers Provide Critical New Insights on DNA Repair
    Researchers at the University of Texas MD Anderson Cancer Center say they have gained new insights on the role of fumarase in DNA repair. They published their study ("Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation”) in Nature Cell Biology.     "Our study showed that the enzymatic activity of the metabolicRead more
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Researchers Provide Critical New Insights on DNA Repair
Aug 10,2015
Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
Multidrug resistance is a serious threat to public health. Proton motive force-driven antiporters from the major facilitator superfamily (MFS) constitute a major group of multidrug-resistance transporters. Currently, no reports on crystal structures of MFS antiporters in complex with their substrates exist. The E. coli MdfA transporter is a well-studied model system for biochemical analyses ofRead more
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Aug 10,2015
Urine Proteins Point to Early-Stage Pancreatic Cancer
    Raising hopes for a simple, noninvasive, inexpensive, and easily repeatable test for pancreatic cancer, scientists at Barts Cancer Institute, Queen Mary University, have developed a three-protein biomarker panel that can screen urine samples to identify pancreatic cancer when it is still in its early stages. The panel, the scientists say, has already demonstrated better thanRead more
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Aug 07,2015
Biopharmas Team Up with U.K.’s 100,000 Genomes Project
    Ten biopharma companies have joined together to create the Genomics Genomics Expert Network for Enterprises (GENE) Consortium, which will oversee a year-long trial designed to integrate industry expertise into the 100,000 Genomes Project—the U.K.'s effort to catapult itself to global leadership in genetic research into cancer and rare diseases.     Through the GENE Consortium, the companiesRead more
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Aug 07,2015
Purification of Recombinant AAV Vectors for Preclinical Applications
    Cesium chloride- and iodixanol-based density gradients represent the core step in most protocols for serotype-independent adeno-associated virus (AAV) purification. However, despite controversial reports about purity and bioactivity of AAV vectors derived from each of these protocols, systematic comparisons of variants of these methods are sparse. Strobel and colleagues from Boehringer Ingelheim Pharma recently carried outRead more
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