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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Aug 06,2015
Link between Mitochondrial Protein and Heart Failure Uncovered
    While all cells in the body rely on metabolic pathways that take place within the mitochondria, the cells of some organs, such as the brain and heart, have an essential demand for constant energy. Maintaining the proper mitochondrial homeostasis is critical for overall tissue health, as defective mitochondria have been linked to a number ofRead more
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Aug 06,2015
Biomolecules Sorted with Catch-and-Release System
A microtubule-inspired microfluidic system that resembles a microscopic forest of arms can pluck biomolecules out of liquid mixtures, carry them from one chemical stream to another, and then release them. The system, which is dynamic and tunable, may be suitable for applications in clinical diagnostics, target characterization, environmental analysis, and chemical purification. Each "arm” insideRead more
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Aug 05,2015
Cancer Drug Spending Reaches $100B Mark
Total global spending on cancer medicines reached the $100 billion mark last year, as patients and doctors embraced earlier diagnosis and more effective therapies requiring longer treatment durations, the IMS Institute for Healthcare Informatics said today in a report. The global market for oncology drugs—including those used in supportive care—increased 10.3% last year and hasRead more
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Cancer Drug Spending Reaches $100B Mark
Aug 05,2015
Key Gene Linking Fast-Acting and Slow-Acting Immune Response Found
Australian scientists say they have shown that a specific gene determines the development and function of important cells that bridge the gap between our fast-acting innate and slower-acting adaptive, immune systems. STAT3, as it is known, helps protect against a variety of fungal and bacterial infections, and understanding its role may help in finding waysRead more
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Aug 04,2015
Single Nuclear Protein Orchestrates Stem Cell Development
Think of an especially active, hands-on orchestra conductor who shuns the podium, roams the orchestra pit, and urges principle musicians from diverse ensembles to play together and realize the score. That's roughly what happens during stem cell development, except the conductor is a single "master” growth factor receptor, the orchestra pit is the nucleus, theRead more
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Aug 04,2015
Scientists Use Molecular Can Opener to Target HIV
One of the main roadblocks that have stymied researchers' attempts at generating an effective HIV vaccine is somehow managing to get antibodies and other immune cells to attack the appropriate targets that are practically hermetically sealed within the virus. However, scientists at the Montreal University Health Centre (CHUM) believe they have found what amounts toRead more
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Aug 04,2015
Cancer Xenograft Models
Cancer Xenograft Models Introduction Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans. The most common models are xenografts of human tumors and cell lines grown subcutaneously in immunodeficient mice such as athymic (nude) or severe combined immuneRead more
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Cancer Xenograft Models
Aug 03,2015
Highly Conserved DNA Repair Proteins Have Role in Cancer Predisposition
During evolution and development of a species, the replication of the organism's genome can lead to a duplication of certain genes that evolve new functions. These so-called paralogs are found throughout the genome of humans, as well as other organisms, and are associated with a variety of cellular processes. Yet, the paralogs that are involvedRead more
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Aug 03,2015
Bioinformatics Program Matches Cancer Patients with Treatments
Scientists at the University of Colorado Cancer Center have described a new tool that reportedly improves the ability to match drugs to disease. The Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best kinase inhibitor to silence these dangerous genetic causes of disease,Read more
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Bioinformatics Program Matches Cancer Patients with Treatments
Jul 31,2015
Tumor Microenvironment Impacts Cancer Subtype Progression
Scientists at Cold Spring Harbor Laboratory (CSHL) report that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment, which is the area of tissue in which the tumor is embedded.
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Tumor Microenvironment Impacts Cancer Subtype Progression