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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Apr 14,2021
Some tips in the process of protein purification experiments
Newbies in protein purification have benefits. Qianchun Biotech will list some of the most commonly used purification processes and conceptual methods. Escherichia coli (E. coli referred to here is a recombinant protein that is not secreted into the culture medium). About the amount of bacteria The genetically engineered protein expressed in Escherichia coli is theRead more
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Some tips in the process of protein purification experiments
Apr 14,2021
Advantages and principles of protein purification His-tag
1.What is His-tag? His-tag monoclonal antibody is also called 6His-tag monoclonal antibody, or 6His monoclonal antibody. It is prepared with mice. His can be adsorbed on a nickel column and used to purify recombinant proteins, regardless of whether the expressed protein is soluble or Inclusion bodies can be purified by immobilized metal ion affinity chromatographyRead more
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Advantages and principles of protein purification His-tag
Apr 14,2021
How to establish a protein purification process?
When establishing a protein purification process, the most important thing is to consider that the purified protein should be able to meet its subsequent application requirements. The quantity and purity of the protein must meet the requirements of experimental analysis. Moreover, because follow-up studies require active proteins that maintain a well-folded structure, information about proteinRead more
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How to establish a protein purification process?
Apr 13,2021
Principle of protein purification method
The reason why a protein can be purified from a mixture of thousands of proteins is that different proteins have great differences in many of their physical, chemical, and biological properties. These properties are due to the sequence and number of amino acids in the protein. Due to the difference, the amino acid residues connectedRead more
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Principle of protein purification method
Apr 12,2021
Summary of preclinical and clinical research progress of anti-tumor antibodies targeting CD47
The CD47 antibody out-license deal reached by Tianjing Bio and Abbvie this week, which reached nearly 2 billion US dollars, once again proved the superstar status of CD47 antibody. Recently, this article titled "Preclinical and Clinical Development of Therapeutic Antibodies Targeting Functions of CD47 in the Tumor Microenvironment” was published by Antibody Therapeutics.
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Summary of preclinical and clinical research progress of anti-tumor antibodies targeting CD47
Apr 12,2021
Recommendations for Phase I Preclinical Preparation Development
01 Solid form Regarding the solid form of the new molecular entity (NCE), different companies generally determine it at different points in time and also adopt different decision-making processes. However, according to the author's experience, before the start of the IND study, it is determined that the stable solid form that can be developed byRead more
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Recommendations for Phase I Preclinical Preparation Development
Apr 12,2021
What is Preclinical Testing of Vaccines​?
What is the Main Purpose of Preclinical Testing? Pre-clinical testing must be performed before clinical trials. The purpose of pre-clinical trials is to use human cell cultures or animals to evaluate the potential toxicity of a new therapeutic drug before the "in vivo” test is performed by human participants. The main goals of preclinical studiesRead more
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What is Preclinical Testing of Vaccines​?
Apr 09,2021
Pre-clinical CRO industry analysis
(1) Introduction to the pre-clinical CRO industry The pre-clinical research business of our new drug involves pre-clinical compound screening, pre-clinical phase and clinical phase 1, with pre-clinical phase as the main focus. Pre-clinical research refers to conducting laboratory research and live animal research on candidate drugs obtained in the research phase of the compound underRead more
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Pre-clinical CRO industry analysis
Apr 09,2021
What are Preclinical Trials?
Preclinical research refers to chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics and toxicology research, and pharmacy research conducted before the drug enters clinical research. Preclinical trials Content Preclinical research of drugs for drug registration, including drug synthesis technology, extraction methods, physical and chemical properties and purity, dosage form selection, prescriptionRead more
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What are Preclinical Trials?
Apr 08,2021
Points of Interest in Non-clinical Studies of Metabolites in the Development of Small Molecule Drugs
There may be differences in the metabolic characteristics of small molecule drugs in experimental animal species and humans, and there may be unique or high-level metabolites in humans. If these metabolites are not identified or fully evaluated in non-clinical safety trials, the safety of human medications may not be fully guaranteed. Depending on the specificRead more
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Points of Interest in Non-clinical Studies of Metabolites in the Development of Small Molecule Drugs